RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
Sail
RNA ID
RNA Type
lncrna
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
NA
Target
NA
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
SAIL: a new conserved anti-fibrotic lncRNA in the heart
Year
2021
Function
"SAIL inhibited the fibrotic process by directly binding with SAFB via 23 conserved nucleotide sequences, in turn blocked the access of SAFB to RNA pol II (RNA polymerase II) and reduced the transcription of fibrosis-related genes. Intriguingly,the human conserved fragment of SAIL (hSAIL) significantly suppressed the proliferation and collagen production of human cardiac fibroblasts."
RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
Sail
RNA ID
RNA Type
lncrna
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
NA
Target
NA
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
SAIL: a new conserved anti-fibrotic lncRNA in the heart
Year
2021
Function
"SAIL inhibited the fibrotic process by directly binding with SAFB via 23 conserved nucleotide sequences, in turn blocked the access of SAFB to RNA pol II (RNA polymerase II) and reduced the transcription of fibrosis-related genes. Intriguingly,the human conserved fragment of SAIL (hSAIL) significantly suppressed the proliferation and collagen production of human cardiac fibroblasts."